Latest insider trades

P = PurchaseS = SaleM = Option exerciseA = Award/GrantF = Tax withholdingG = Gift

• Thompson Peter A.sold85,918 shares ofSIONat $44.86$3.9MJul 9Details
• ORBIMED ADVISORS LLCsold85,918 shares ofSIONat $44.86$3.9MJul 9Details
• Fitzpatrick Jennifersold10,250 shares ofSIONat $43.596$447KJul 7Details
• Fitzpatrick Jenniferexercised10,250 shares ofSIONat $6.11$63KJul 7Details
• Thompson Peter A.sold115,844 shares ofSIONat $45.5$5.3MJul 2Details
• ORBIMED ADVISORS LLCsold115,844 shares ofSIONat $45.5$5.3MJul 2Details
• Booth Brucegranted17,340 shares ofSIONat $0Jun 18Details
• Ruddy Marcella K.granted17,340 shares ofSIONat $0Jun 18Details
• Fleming Harold Edwardgranted17,340 shares ofSIONat $0Jun 18Details
• Viney Joanne L.granted17,340 shares ofSIONat $0Jun 18Details
• Resnick Joshuagranted17,340 shares ofSIONat $0Jun 18Details
• Stelzer Lauriegranted17,340 shares ofSIONat $0Jun 18Details
• Clancy Paul Jgranted17,340 shares ofSIONat $0Jun 18Details
• Thompson Peter A.granted17,340 shares ofSIONat $0Jun 18Details
• RA CAPITAL MANAGEMENT, L.P.granted17,340 shares ofSIONat $0Jun 18Details
• ORBIMED ADVISORS LLCsold101 shares ofSIONat $44.49$4KMay 29Details
• Thompson Peter A.sold101 shares ofSIONat $44.49$4KMay 29Details
• Thompson Peter A.sold184,639 shares ofSIONat $46.22$8.5MMay 11Details
• Thompson Peter A.sold59,767 shares ofSIONat $44.58$2.7MMay 11Details
• Thompson Peter A.sold48,546 shares ofSIONat $44.61$2.2MMay 11Details
• ORBIMED ADVISORS LLCsold184,639 shares ofSIONat $46.22$8.5MMay 11Details
• ORBIMED ADVISORS LLCsold59,767 shares ofSIONat $44.58$2.7MMay 11Details
• ORBIMED ADVISORS LLCsold48,546 shares ofSIONat $44.61$2.2MMay 11Details
• ORBIMED ADVISORS LLCsold2,948 shares ofSIONat $44.52$131KApr 21Details
• ORBIMED ADVISORS LLCsold52,397 shares ofSIONat $44.68$2.3MApr 21Details
• Thompson Peter A.sold2,948 shares ofSIONat $44.52$131KApr 21Details
• Thompson Peter A.sold52,397 shares ofSIONat $44.68$2.3MApr 21Details
• Thompson Peter A.sold47,814 shares ofSIONat $44.51$2.1MApr 16Details
• Thompson Peter A.sold226,906 shares ofSIONat $45.34$10.3MApr 16Details
• Thompson Peter A.sold235,863 shares ofSIONat $44.64$10.5MApr 16Details
• ORBIMED ADVISORS LLCsold226,906 shares ofSIONat $45.34$10.3MApr 16Details
• ORBIMED ADVISORS LLCsold235,863 shares ofSIONat $44.64$10.5MApr 16Details
• ORBIMED ADVISORS LLCsold47,814 shares ofSIONat $44.51$2.1MApr 16Details
• Fitzpatrick Jennifersold10,250 shares ofSIONat $33.856$347KMar 6Details
• Fitzpatrick Jenniferexercised10,250 shares ofSIONat $6.11$63KMar 6Details
• ORBIMED ADVISORS LLCsold1,890 shares ofSIONat $44.57$84KFeb 4Details
• ORBIMED ADVISORS LLCsold29,063 shares ofSIONat $44.58$1.3MFeb 4Details
• Thompson Peter A.sold29,063 shares ofSIONat $44.58$1.3MFeb 4Details
• Thompson Peter A.sold1,890 shares ofSIONat $44.57$84KFeb 4Details
• TPG GP A, LLCsold250,000 shares ofSIONat $40$10MJan 26Details
• Beer Caroline Starkgranted139,340 shares ofSIONat $0Jan 6Details
• Fitzpatrick Jennifergranted103,140 shares ofSIONat $0Jan 6Details
• McKee Charlottegranted155,700 shares ofSIONat $0Jan 6Details
• Ridloff Elenagranted165,440 shares ofSIONat $0Jan 6Details
• Cloonan Michaelgranted436,100 shares ofSIONat $0Jan 6Details
• ORBIMED ADVISORS LLCsold33,356 shares ofSIONat $44.55$1.5MDec 29Details
• Thompson Peter A.sold33,356 shares ofSIONat $44.55$1.5MDec 29Details
• ORBIMED ADVISORS LLCsold900 shares ofSIONat $44.5$40KDec 19Details
• ORBIMED ADVISORS LLCsold100 shares ofSIONat $44.49$4KDec 19Details
• ORBIMED ADVISORS LLCsold875 shares ofSIONat $44.49$39KDec 19Details