Latest insider trades

P = PurchaseS = SaleM = Option exerciseA = Award/GrantF = Tax withholdingG = Gift

• Thompson Peter A.sold875 shares ofSIONat $44.49$39KDec 19Details
• Thompson Peter A.sold100 shares ofSIONat $44.49$4KDec 19Details
• Thompson Peter A.sold900 shares ofSIONat $44.5$40KDec 19Details
• Fitzpatrick Jennifersold10,250 shares ofSIONat $40.52$415KDec 9Details
• Fitzpatrick Jenniferexercised10,250 shares ofSIONat $6.11$63KDec 9Details
• ORBIMED ADVISORS LLCsold11,890 shares ofSIONat $44.6$530KNov 26Details
• Thompson Peter A.sold1,600 shares ofSIONat $44.49$71KNov 26Details
• Thompson Peter A.sold11,890 shares ofSIONat $44.6$530KNov 26Details
• Thompson Peter A.sold94,583 shares ofSIONat $44.54$4.2MNov 26Details
• ORBIMED ADVISORS LLCsold94,583 shares ofSIONat $44.54$4.2MNov 26Details
• ORBIMED ADVISORS LLCsold1,600 shares ofSIONat $44.49$71KNov 26Details
• RA CAPITAL MANAGEMENT, L.P.sold150 shares ofSIONat $39.89$6KNov 24Details
• RA CAPITAL MANAGEMENT, L.P.sold1,235 shares ofSIONat $39.89$49KNov 24Details
• RA CAPITAL MANAGEMENT, L.P.sold801 shares ofSIONat $39.89$32KNov 24Details
• RA CAPITAL MANAGEMENT, L.P.sold947 shares ofSIONat $39.89$38KNov 24Details
• RA CAPITAL MANAGEMENT, L.P.sold96 shares ofSIONat $40.5$4KNov 24Details
• RA CAPITAL MANAGEMENT, L.P.sold788 shares ofSIONat $40.5$32KNov 24Details
• RA CAPITAL MANAGEMENT, L.P.sold512 shares ofSIONat $40.5$21KNov 24Details
• RA CAPITAL MANAGEMENT, L.P.sold604 shares ofSIONat $40.5$24KNov 24Details
• RA CAPITAL MANAGEMENT, L.P.sold1,210 shares ofSIONat $39.5$48KNov 24Details
• RA CAPITAL MANAGEMENT, L.P.sold9,924 shares ofSIONat $39.5$392KNov 24Details
• RA CAPITAL MANAGEMENT, L.P.sold6,440 shares ofSIONat $39.5$254KNov 24Details
• RA CAPITAL MANAGEMENT, L.P.sold7,609 shares ofSIONat $39.5$301KNov 24Details
• RA CAPITAL MANAGEMENT, L.P.sold12,126 shares ofSIONat $40.01$485KNov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold2,182 shares ofSIONat $40.2$88KNov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold17,913 shares ofSIONat $40.2$720KNov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold11,626 shares ofSIONat $40.2$467KNov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold13,734 shares ofSIONat $40.2$552KNov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold1,701 shares ofSIONat $41.05$70KNov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold13,964 shares ofSIONat $41.05$573KNov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold9,063 shares ofSIONat $41.05$372KNov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold10,707 shares ofSIONat $41.05$440KNov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold53 shares ofSIONat $42.1$2KNov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold433 shares ofSIONat $42.1$18KNov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold280 shares ofSIONat $42.1$12KNov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold2,728 shares ofSIONat $39.57$108KNov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold1,770 shares ofSIONat $39.57$70KNov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold2,092 shares ofSIONat $39.57$83KNov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold2,276 shares ofSIONat $40.01$91KNov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold9 shares ofSIONat $40.61$365Nov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold8 shares ofSIONat $40.61$325Nov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold12 shares ofSIONat $40.61$487Nov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold2 shares ofSIONat $40.61$81Nov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold332 shares ofSIONat $39.57$13KNov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold331 shares ofSIONat $42.1$14KNov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold18,684 shares ofSIONat $40.01$748KNov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold14,325 shares ofSIONat $40.01$573KNov 19Details
• RA CAPITAL MANAGEMENT, L.P.sold14,116 shares ofSIONat $39.5$558KOct 28Details
• RA CAPITAL MANAGEMENT, L.P.sold122,271 shares ofSIONat $39.5$4.8MOct 28Details
• RA CAPITAL MANAGEMENT, L.P.sold66,672 shares ofSIONat $39.5$2.6MOct 28Details