Latest insider trades

P = PurchaseS = SaleM = Option exerciseA = Award/GrantF = Tax withholdingG = Gift

• Booth Brucesold5,125 shares ofKYMRat $91.23$468KDec 12Details
• Booth Brucesold976 shares ofKYMRat $91.23$89KDec 12Details
• Booth Brucesold570 shares ofKYMRat $91.04$52KDec 12Details
• Booth Brucesold108 shares ofKYMRat $91.04$10KDec 12Details
• BAKER BROS. ADVISORS LPbought167,192 shares ofKYMRat $86$14.4MDec 11Details
• BAKER BROS. ADVISORS LPbought1,838,621 shares ofKYMRat $86$158.1MDec 11Details
• Albers Jeffrey W.exercised5,000 shares ofKYMRat $14.18$71KDec 8Details
• Albers Jeffrey W.sold2,748 shares ofKYMRat $89.323$245KDec 8Details
• Albers Jeffrey W.sold2,252 shares ofKYMRat $90.304$203KDec 8Details
• Gollob Jaredexercised49,307 shares ofKYMRat $5.33$263KDec 8Details
• Gollob Jaredsold13,759 shares ofKYMRat $87.371$1.2MDec 8Details
• Gollob Jaredsold18,357 shares ofKYMRat $88.022$1.6MDec 8Details
• Gollob Jaredsold3,929 shares ofKYMRat $89.426$351KDec 8Details
• Gollob Jaredsold8,562 shares ofKYMRat $90.123$772KDec 8Details
• Gollob Jaredsold3,300 shares ofKYMRat $91.464$302KDec 8Details
• Gollob Jaredsold1,400 shares ofKYMRat $92.19$129KDec 8Details
• Mainolfi Nelloexercised100,000 shares ofKYMRat $2.08$208KDec 8Details
• Mainolfi Nellosold100,000 shares ofKYMRat $89.17$8.9MDec 8Details
• Mainolfi Nelloexercised30,000 shares ofKYMRat $2.08$62KOct 29Details
• Mainolfi Nellosold1,862 shares ofKYMRat $59.723$111KOct 29Details
• Mainolfi Nellosold24,511 shares ofKYMRat $61.019$1.5MOct 29Details
• Mainolfi Nellosold3,627 shares ofKYMRat $61.458$223KOct 29Details
• Gollob Jaredexercised28,999 shares ofKYMRat $1.31$38KOct 15Details
• Gollob Jaredexercised22,210 shares ofKYMRat $2.08$46KOct 15Details
• Gollob Jaredsold29,264 shares ofKYMRat $60.37$1.8MOct 15Details
• Gollob Jaredsold8,963 shares ofKYMRat $61.493$551KOct 15Details
• Gollob Jaredsold14,896 shares ofKYMRat $62.723$934KOct 15Details
• Gollob Jaredsold6,453 shares ofKYMRat $63.087$407KOct 15Details
• Albers Jeffrey W.exercised5,000 shares ofKYMRat $10.34$52KOct 14Details
• Albers Jeffrey W.sold5,000 shares ofKYMRat $59.19$296KOct 14Details
• Gollob Jaredexercised800 shares ofKYMRat $1.31$1KOct 14Details
• Gollob Jaredexercised673 shares ofKYMRat $2.08$1KOct 14Details
• Gollob Jaredsold3,114 shares ofKYMRat $60$187KOct 14Details
• Jacobs Bruce N.exercised79,220 shares ofKYMRat $2.08$165KSep 17Details
• Jacobs Bruce N.sold79,220 shares ofKYMRat $50.005$4MSep 17Details
• Jacobs Bruce N.exercised42,246 shares ofKYMRat $0Sep 17Details
• Jacobs Bruce N.exercised36,974 shares ofKYMRat $0Sep 17Details
• Mainolfi Nelloexercised30,000 shares ofKYMRat $2.08$62KSep 16Details
• Mainolfi Nellosold30,000 shares ofKYMRat $49$1.5MSep 16Details
• Adams Briangranted52,500 shares ofKYMRat $0Sep 3Details
• Adams Briangranted105,000 shares ofKYMRat $0Sep 3Details
• BVF PARTNERS L P/ILbought142,604 shares ofKYMRat $44$6.3MJul 1Details
• BVF PARTNERS L P/ILbought115,783 shares ofKYMRat $44$5.1MJul 1Details
• BVF PARTNERS L P/ILbought58,780 shares ofKYMRat $44$2.6MJul 1Details
• BVF PARTNERS L P/ILgranted16,000 shares ofKYMRat $0Jul 1Details
• BVF PARTNERS L P/ILgranted16,000 shares ofKYMRat $0Jun 28Details
• BVF PARTNERS L P/ILbought550,425 shares ofKYMRat $25.25$13.9MJan 9Details
• BVF PARTNERS L P/ILbought375,856 shares ofKYMRat $25.25$9.5MJan 9Details
• BVF PARTNERS L P/ILbought52,733 shares ofKYMRat $25.25$1.3MJan 9Details