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© 2026 InsiderTradingScreener.com. Data from SEC EDGAR Form 4 filings.For informational purposes only. Not financial advice.

Home/Companies/Spyre Therapeutics, Inc.

Spyre Therapeutics, Inc.

79 insider trades tracked

SYRE

Insider trades

79

Bought (open market)

$0

Sold (open market)

$426.4M

Unique insiders

10

12-month activity

Monthly insider buy vs sell totals for Spyre Therapeutics, Inc..

BuysSells

Recent insider trades

Most recent Form 4 filings for Spyre Therapeutics, Inc..

Burrows Scott Lsold1,725 shares ofSYREat $88.37$152KJul 2Details
Burrows Scott Lsold5,775 shares ofSYREat $87.55$506KJul 2Details
Burrows Scott Lexercised7,500 shares ofSYREat $14.5$109KJul 2Details
Sloan Sheldonsold1,834 shares ofSYRE

Insiders at this company

Executives and directors who have filed Form 4s.

Turtle Cameron26 trades
Burrows Scott L20 trades
Sloan Sheldon17 trades
HENDERSON MICHAEL THOMAS7 trades
Fairmount Funds Management LLC4 trades
King-Jones Heidy1 trades
McKenna Mark C.1 trades
Stelzer Laurie1 trades

Explore insider screeners

Latest CEO & CFO Purchases Latest CEO & CFO Sales Director Purchases Officer Purchases Top Purchases This Week Top Sales This Week Top Officer Buys (Month)10% Owner Filings 10b5-1 Planned Trades Discretionary Trades Buy/Sell Ratios Politician–Insider Overlap

at $88.34

$162KJul 2Details

Sloan Sheldonsold6,500 shares ofSYREat $87.52$569KJul 2Details

Sloan Sheldonexercised8,334 shares ofSYREat $27.46$229KJul 2Details

Turtle Cameronsold590 shares ofSYREat $88.91$52KJul 2Details

Turtle Cameronsold4,234 shares ofSYREat $88.12$373KJul 2Details

Turtle Cameronsold10,176 shares ofSYREat $87.44$890KJul 2Details

Burrows Scott Lsold10,000 shares ofSYREat $87.14$871KJun 26Details

Burrows Scott Lsold5,000 shares ofSYREat $87.12$436KJun 26Details

Burrows Scott Lexercised15,000 shares ofSYREat $14.5$218KJun 26Details

Fairmount Funds Management LLCtraded16,667 shares ofSYREat $0Jun 23Details

Fairmount Funds Management LLCsold4,684,781 shares ofSYREat $85.31$399.7MJun 23Details

Fairmount Funds Management LLCtraded666,680 shares ofSYREJun 23Details

HENDERSON MICHAEL THOMASsold20,000 shares ofSYREat $100$2MJun 23Details

Sloan Sheldonsold8,333 shares ofSYREat $75$625KJun 3Details

Sloan Sheldonexercised8,333 shares ofSYREat $27.46$229KJun 3Details

Turtle Cameronsold3,294 shares ofSYREat $71.38$235KJun 3Details

Turtle Cameronsold8,149 shares ofSYREat $70.5$575KJun 3Details

Turtle Cameronsold3,557 shares ofSYREat $69.4$247KJun 3Details

Burrows Scott Lsold3,100 shares ofSYREat $72.06$223KJun 3Details

Burrows Scott Lsold2,599 shares ofSYREat $70.77$184KJun 3Details

Burrows Scott Lsold1,801 shares ofSYREat $69.75$126KJun 3Details

Burrows Scott Lexercised7,500 shares ofSYREat $14.5$109KJun 3Details

Milligan Sandragranted8,026 shares ofSYREat $0May 29Details

Fairmount Funds Management LLCgranted8,026 shares ofSYREat $0May 29Details

Albers Jeffrey W.granted8,026 shares ofSYREat $0May 29Details

HENDERSON MICHAEL THOMASgranted8,026 shares ofSYREat $0May 29Details

Stelzer Lauriegranted8,026 shares ofSYREat $0May 29Details

View all trades for SYRE →

Albers Jeffrey W.

1 trades

Milligan Sandra1 trades

Spyre Therapeutics, Inc. (SYRE) — Insider Trading Activity | Insider Trading Screener