Opaleye Management Inc. has filed 170 Form 4 transactions across seven companies, with a near-even split in dollar terms. Open-market purchases total $20.83 million, while open-market sales total $22.05 million. That balance, however, masks a sharp directional shift in the most recent filings. The last 25 trades are all purchases, with zero sales.
The buying is concentrated in two tickers: GRCE and ACOG. Since September 16, Opaleye has made 25 open-market buys in these names, ranging from $3,489.64 on October 5 to $227,984.40 on September 16. The largest single purchase was the ACOG buy on September 16, followed by a $190,973.59 ACOG purchase on October 15 and a $165,634.03 ACOG buy on October 1. GRCE purchases have been smaller and more frequent, with 16 buys in the same window, including two identical $20,519.10 transactions on September 21 and two identical $11,167.80 buys on September 23.
The pattern is consistent. Opaleye has bought GRCE on nearly every trading day from late September through late October, with amounts that vary from a few thousand dollars to over $100,000. ACOG purchases are less frequent but larger, with five buys exceeding $100,000. The most recent filing, an $117,408.01 GRCE purchase on October 26, continues the trend. The firm has not filed an open-market sale since this buying run began.
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