Opaleye Management Inc. has filed 140 Form 4 trades across seven companies, with a clear recent bias toward open-market buying. The firm's total disclosed purchases reached $18,008,304.35, against $22,049,178.77 in sales, but the recent activity is one-sided. In the last two months, Opaleye has recorded 23 open-market purchases and just two sales.
The dominant position is SLGL, where Opaleye has made 13 separate purchases between July 10 and September 9, 2026. Those buys range from $14,994.70 on August 31 to a single $1,376,137.49 purchase on August 28. The firm also bought ACOG in five transactions from July 22 to August 3, including a $1,098,574.59 purchase on July 22 and a $400,000 buy on August 3. Smaller purchases appeared in GRCE on August 14 for $24,206.16. The only sales were two ETON dispositions on July 14, totaling $1,063,032.88.
The pattern is concentrated accumulation in SLGL and ACOG, with the largest dollar amounts arriving in late August. The ETON sales are the only recent reductions, and they are small relative to the buying volume. The firm has not reported any option exercises, grants, or tax-withholding events in this window, which means the Form 4 codes are almost entirely P for purchase and S for sale. Opaleye is adding to positions, not trimming them, and the pace of SLGL buying accelerated through August and into September.
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